Phenotypic manifestations of arterial hypertension according to polymorphism of vitamin D receptor gene

Objective. To determine the phenotypic manifestations of essential arterial hypertension (EAH) according to vitamin D receptor gene polymorphism (VDR rs10735810, rs2228570).Material and methods. The case-control study involved 100 patients with EAH stage II, 1-3 degrees blood pressure (BP), high very cardiovascular risk, 21% (21) men, 79% (79) women. mean age was 59.86 ± 6.22 y.o. control group consisted 60 healthy individuals, comparable in gender. VDR (rs10735810, rs2228570) performed a qualitative polymerase chain reaction real-time. Results. Almost half elevated normal BP (44.4%) 34% 2-3 d. there is concomitant diabetes mellitus (DM) type 2, while for 1 it only 19%. Obesity shown 53% EAH: average - 21%, among 25%. In group, 16% suffered from obesity. distribution genotypes presence DM showed that present 35% AA-genotype, which 1.6 times more often than GG-genotype (22%). Most smokers (26%), twice as common those AA- AG-genotype (13% 14%, respectively). most met carriers 74%, 14%. An level waist-hip ratio (WHR) women 80% AA-genotype carriers, all had values. 76% 81% WHR increased by 2.3 2.8 times, respectively, group. Deviations systolic diastolic polymorphic variants have not been established.Conclusions. associated 2 women; BMI, especially men.